How to easily participate in cancer research?
The Institut Bordet Tumour Bank or Tumour Biobank is a collection of samples of human body material (tumour tissue residue, blood samples) and of associated data preserved in optimum conditions for their future use in research. It constitutes a crucial link between diagnosis and fundamental, translational and clinical research. Its activity is subject to strict legislation.
The development of personalised medicine and of immunotherapy in oncology requires the exploration of new biomarkers identifiable in tumour tissue, but also in blood. The role of the Tumour Bank is to collect and supply to scientific research laboratories very high quality, diversified, biological samples in sufficient quantity, accompanied by complete clinical data to enable them to carry out their research. The objective is to understand how tumour ‘machinery’ operates and the strategy that allows it to escape the vigilance and immune defences of its host.
The Tumour Bank forms part of the Anatomical Pathology Department, enabling full and accurate analysis of tumours by pathologists prior to their preservation. It also forms an integral part of other Belgian biobanks – the Cancer Register Virtual Catalogue, BWB (Wallonia-Brussels BioBank) and of 2 European biobanks: the BBMRI and ESBB. Contact via these networks between different Belgian and international research teams facilitates the establishment of links and skill sharing.
The Institut Bordet Tumour Bank has been ISO90001 certified since 2012 – a guarantee of quality. The robust system put in place for the quality control of our samples enables us to support numerous research projects every year. This is evidenced in the quality of the scientific publications that result from these.
- Created: 2010
- More than 16,000 frozen tissue samples available
- Samples provided by more than 10,000 patients
- More than 65 projects using the samples collected
- Digital Pathology
Digital pathology is becoming increasingly important in current practice, particularly in research. The Friends of the Institut Bordet have funded part of our Digital Pathology platform. The process of digitising microscopy slides makes it possible to use software to process images. As a result, precise analysis of different cell populations – solid tumour inflammatory infiltrates, for example – can be carried out. These studies will be transposed to a clinical setting, notably to assess whether or not a particular immunotherapy treatment might be beneficial to patients. In addition, hot-spots (concentrations of cell markers) are identified and analysed.
- Laser Microdissection
Laser microdissection or Laser Capture/Cutting Microdissection (LCM) is a technology that allows the isolation, under morphological control, of cells of interest from tissue sections using a laser beam. This project, supported by the Friends of the Institut Bordet, will make it possible to study tumour heterogeneity at single-cell-type level.
The Tumour Bank not only supplies biological material, it also develops its own scientific projects.
Activating phosphorylation of CDK4: Use to predict tumour responsiveness to CDK4 inhibitory drugs in order to extend these drugs to cancers lacking efficient therapies
Tumor Banks: A Quality Control Scheme Proposal
Craciun L, Spinette SA, Rassy M, Salgado R, de Wind A, Demetter P, Verset L, Gomez-Galdon M, Chintinne M, Sirtaine N, de St Aubain N, Laios I, Roy F, Larsimont D.
Front Med (Lausanne). 2019
Tumor infiltrating B-cells signal functional humoral immune responses in breast cancer
Garaud S, Buisseret L, Solinas C, Gu-Trantien C, de Wind A, Van den Eynden G, Naveaux C, Lodewyckx JN, Boisson A, Duvillier H, Craciun L, Ameye L, Veys I, Paesmans M, Larsimont D, Piccart-Gebhart M, Willard-Gallo K.
JCI Insight. 2019
BRCA gene mutations do not shape the extent and organization of tumor infiltrating lymphocytes in triple negative breast cancer
Solinas C, Marcoux D, Garaud S, Vitória JR, Van den Eynden G, de Wind A, De Silva P, Boisson A, Craciun L, Larsimont D, Piccart-Gebhart M, Detours V, t'Kint de Roodenbeke D, Willard-Gallo K
Cancer Lett. 2019
Reprogramming of Energy Metabolism: Increased Expression and Roles of Pyruvate Carboxylase in Papillary Thyroid Cancer
Strickaert A, Corbet C, Spinette SA, Craciun L, Dom G, Andry G, Larsimont D, Wattiez R, Dumont JE, Feron O, Maenhaut C.
FOXP1 negatively regulates tumor infiltrating lymphocyte migration in human breast cancer
De Silva P, Garaud S, Solinas C, de Wind A, Van den Eyden G, Jose V, Gu-Trantien C, Migliori E, Boisson A, Naveaux C, Duvillier H, Craciun L, Larsimont D, Piccart-Gebhart M, Willard-Gallo K
Distinctive Desmoplastic 3D Morphology Associated With BRAFV600E in Papillary Thyroid Cancers
Tarabichi M, Antoniou A, Le Pennec S, Gacquer D, de Saint Aubain N, Craciun L, Cielen T, Laios I, Larsimont D, Andry G, Dumont JE, Maenhaut C, Detours V
J Clin Endocrinol Metab. 2018
Inflammatory Stroma of Lymphoepithelioma-like Carcinoma of the Cervix: Immunohistochemical Study of 3 Cases and Review of the Literature
Philippe A, Rassy M, Craciun L, Naveaux C, Willard-Gallo K, Larsimont D, Veys I.
Int J Gynecol Pathol. 2018
Feasibility and clinical impact of routine molecular testing of gastrointestinal cancers at a tertiary centre with a multi-gene, tumor-agnostic, next generation sequencing panel.
Authors : Bregni G, Sticca T, Camera S, Akin Telli T, Craciun L, Trevisi E, Pretta A, Kehagias P, Leduc S, Senti C, Deleporte A, Vandeputte C, Saad ED, Kerger J, Gil T, Piccart-Gebhart M, Awada A, Demetter P, Larsimont D, Hendlisz A, Aftimos P, Sclafani F
Year : 2020
Journal : Acta Oncol
Volume : 59
Pages : 1438-1446
Infiltrative tumour growth pattern correlates with poor outcome in oesophageal cancer.
Authors : Anciaux M, Demetter P, de Wind R, Gomez Galdon M, Vande Velde S, Lens G, Craciun L, Deleruelle A, Larsimont D, Lenaerts T, Sclafani F, Deleporte A, Donckier V, Hendlisz A, Vandeputte C
Year : 2020
Journal : BMJ Open Gastroenterol
Volume : 7
Transcriptional output, cell types densities and normalization in spatial transcriptomics.
Authors : Saiselet M, Rodrigues-Vitória J, Tourneur A, Craciun L, Spinette A, Larsimont D, Andry G, Lundeberg J, Maenhaut C, Detours V
Year : 2020
Journal : J Mol Cell Biol
Retrospective analysis of the immunogenic effects of intra-arterial locoregional therapies in hepatocellular carcinoma: a rationale for combining selective internal radiation therapy (SIRT) and immunotherapy.
Authors : Craciun L, de Wind R, Demetter P, Lucidi V, Bohlok A, Michiels S, Bouazza F, Vouche M, Tancredi I, Verset G, Garaud S, Naveaux C, Galdon MG, Gallo KW, Hendlisz A, Derijckere ID, Flamen P, Larsimont D, Donckier V
Year : 2020
Journal : BMC Cancer
Volume : 20
Pages : 135
Tumor Banks: A Quality Control Scheme Proposal.
Authors : Craciun L, Spinette SA, Rassy M, Salgado R, de Wind A, Demetter P, Verset L, Gomez Galdon M, Chintinne M, Sirtaine N, de St Aubain N, Laios I, Roy F, Larsimont D
Year : 2019
Journal : Front Med (Lausanne)
Volume : 6
Pages : 225