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Laboratory of Oncology and Experimental Surgery (LOCE)

Description

The Laboratory of Oncology and Experimental Surgery (LOCE) is a laboratory at the Institut Bordet recognised by the ULB Faculty of Medicine. It specialises in research into malignant melanoma and pigment cells in general. It combines fundamental research with preclinical and translational research. The LOCE has a self-contained cell culture unit which has established more than 150 primary lines and cultures of normal and tumour cells (mainly melanomas) and adheres to a rigorous quality control programme. The LOCE shares its cell cultures with some 80 research teams around the world.

Research projects

Project 1

EXPLORATION DE L’EFFET RADIOSENSIBILISATEUR DES MÉDICAMENTS CIBLÉS AINSI QUE LEURS COMBINAISONS UTILISÉS DANS LE MÉLANOME POUR AMÉLIORER LA SENSIBILITÉ DES TUMEURS À LA RADIOTHÉRAPIE.

Project 2

PROFILAGE DU KINOME COMME OUTIL PRÉDICTIF DE L’INIHIBITION DES MAPK DANS LE MÉLANOME ET COMME UNE NOUVELLE APPROCHE POUR ÉTUDIER LES MÉCANISMES DE RÉSISTANCE INTRINSÈQUE ET ACQUISE

Project 3

NOUVELLES ASSOCIATIONS MÉDICAMENTEUSES POUR TRAITER LE MÉLANOME MUQUEUX CKIT MUTÉ.

Project 4

LES PROHIBITINES (PHBS) : NOUVELLES CIBLES THÉRAPEUTIQUES POTENTIELLES DANS LE MÉLANOME.

Project 5

NOUVEAUX MARQUEURS PRONOSTIQUES ET DE PROGRESSION AU NIVEAU DES MÉTASTASES DU MÉLANOME.

The team

Head of Unit
Ghanem E. Ghanem

Researchers
Fabrice Journé
Mohammad Krayem
Ahmad Najem
Renato Morandini

PhD students  
Malak Sabbah

Cell Culture Unit
Isabelle Borsu
Marie-Jeanne Gebski

Laboratory Technicians
Philippe Mersch
Marie-Lydie Pelgrims
Lamine Mihoub
Sebahat Yildirim

Data Manager
Laïla Berdouz

Administrative Assistance
Christiane Meunier
Arlinda Rahmani

 Scientific publications

ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection.

Authors : Descamps G, Verset L, Trelcat A, Hopkins C, Lechien JR, Journe F, Saussez S
Year : 2020
Journal : Biology (Basel)
Volume : 9

Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma.

Authors : Wouters J, Kalender-Atak Z, Minnoye L, Spanier KI, De Waegeneer M, Bravo González-Blas C, Mauduit D, Davie K, Hulselmans G, Najem A, Dewaele M, Pedri D, Rambow F, Makhzami S, Christiaens V, Ceyssens F, Ghanem G, Marine JC, Poovathingal S, Aerts S
Year : 2020
Journal : Nat Cell Biol
Volume : 22
Pages : 986-998

Erratum: Krayem, M., et al. Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance Short Title: Sensitivity Prediction to MAPK Inhibitors in Melanoma. <i>

Authors : Krayem M, Aftimos P, Najem A, Hooven TVD, Berg AVD, Hovestad-Bijl L, Wijn R, Hilhorst R, Ruijtenbeek R, Sabbah M, Kerger J, Awada A, Journe F, Ghanem GE
Year : 2020
Journal : Cancers (Basel)
Volume : 12

Toad Venom Antiproliferative Activities on Metastatic Melanoma: Bio-Guided Fractionation and Screening of the Compounds of Two Different Venoms.

Authors : Soumoy L, Wells M, Najem A, Krayem M, Ghanem G, Hambye S, Saussez S, Blankert B, Journe F
Year : 2020
Journal : Biology (Basel)
Volume : 9

Survival and treatment outcome of head and neck cancer patients with pulmonary oligo-metastases.

Authors : Lardinois I, Dequanter D, Lechien JR, Bouland C, Javadian R, Rodriguez A, Loeb I, Journe F, Saussez S
Year : 2020
Journal : Clin Otolaryngol