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Anatomical pathology department

The Anatomical Pathology Department is responsible for analysing tumours sent to it by the Institut Jules Bordet, the CHU St-Pierre and the Ixelles and Molière IRIS SUD hospitals. It is a reference centre in various fields, including the diagnosis of breast, gynaecological, digestive, urogenital, pulmonary, soft tissue and head and neck cancers and lymphomas.

The Department analyses:

  • operative specimens removed during surgical procedures
  • biopsies
  • cytological samples (smears, etc)
  • blood samples for specific cytogenetic examinations (traditional karyotypes for the diagnosis and monitoring of leukaemia and molecular genetic techniques in order to provide prognostic factors).

The Department operates to the ISO 15189 standard.

Research projects

The Anatomical Pathology Department actively collaborates with research teams at the Institut Bordet as part of translational research. In addition, numerous multicentre clinical studies (EORTC, BIG, etc) are coordinated from an anatomopathological viewpoint by the Department which has thus become a central reference laboratory. We are also conducting more specific projects, including:

  

Project 1

Optimisation of preanalytic stages for sequencing. Influence of the preanalytic stage on the detection of gene mutations via next-generation sequencing (NGS).

Project 2

Digital imaging analysis evaluation of proliferation markers Ki67, MCM2 and Geminin in breast cancer in the Anatomical Pathology Department’s Genomic Grade cohort.
  • Project leader : Denis Larsimont,
  • Collaboration : Vincent Detour, ULB
  • Funding : Fonds Lambeau-Marteaux

Project 3

Quality control by infrared spectroscopy. Analysis of the quality and preservation (stability) of proteins from tumour bank frozen samples by infrared spectroscopy.

Project 4

Liquid biopsies. Tumour bank extension to blood/plasma samples thanks to the funding of plasma stabilising tubes by Les Amis de l’IJB. Qualitative and quantitative analysis of tumour DNA in plasma.

Project 5

Analysis of intra- and peritumoral inflammatory infiltrate in patients who have undergone surgery for hepatocellular carcinoma after intra-arterial radio-embolization. 

Project 6

CEA and ctDNA, post-surgery prognostic factors of primary and hepatic metastatic colorectal cancers.

Our team

Pathologists
- Pr D. Larsimont, (Head of Department)
  Tel : + 32 (0)2 541 31 15
- Dr M. Chintinne (Molecular Biology and Sequencing)
  Tel : + 32 (0)2 541 33 13
- Dr N. de Saint Aubain (immunohistochemistry)
  Tel :+ 32 (0)2 541 31 19
- Dr R. de Wind (Cytology)
  Tel :+ 32 (0)2 541 30 34
- Dr D. d’Olne, Consultant
  Tel :+ 32 (0)2 541 33 13
- Dr M. Gomez Galdon (Macroscopy)
  Tel :+ 32 (0)2 541 33 13
- Dr P. Heimann (Cytogenetic)
  Tel :+ 32 (0)2 541 31 44
- Dr N. Sirtaine (Histology)
  Tel :+ 32 (0)2 541 31 19
- Dr A. Theunis, Consultant
  Tel :+ 32 (0)2 541 31 19
- Prof. P. Demetter (Head of Clinic)
  Tel : + 32 (0)2 541 36 98
- Dr L. Verset (Head of Clinic ajunct)
  Tel : + 32 (0)2 541 33 13
- Dr S. Kacar, PG
  Tel :+ 32 (0)2 541 34 93
- Dr R Dehon, PG
  Tel : + 32 (0)2 541 34 93

Secretariat 
- Permanence (Tel : + 32 (0)2 541 73 23)
- Patricia Hoffman, Secretary
  Tel : + 32 (0)2 541 31 05

Quality Cell
- Ioanna Laïos  
  Tel : + 32 (0)2 541 73 10
Françoise Roy  
  Tel : + 32 (0)2 541 33 94

Clinical Studies
- Dr Sc L. Craciun, Coordinator
  Tel :+ 32 (0)2 541 72 16

Tumour bank
Dr Sc L. Craciun, Coordinator
A. Spinette

26/02/2020

 Scientific publications

Guidelines for an optimal management of a malignant colorectal polyp. What is essential in a pathology report ?

Authors : Dano H, Baldin P, Demetter P, Driessen A, Hoorens A, Sagaert X, Van Huysse J, Verset L, Jouret-Mourin A
Year : 2020
Journal : Acta Gastroenterol Belg
Volume : 83
Pages : 53-59

Q-fever associated granulomatous hepatitis.

Authors : Dauby N, Gomez Galdon M, Montesinos C, Van Esbroeck M, Sersté T
Year : 2020
Journal : Int J Infect Dis

Vulval Intestinal/Enteric Heterotopia in a Patient with Crohn's Disease.

Authors : Noël JC, Rotea C, Verset L, Catteau X
Year : 2020
Journal : Case Rep Pathol
Volume : 2020
Pages : 6203826

Indications of next-generation sequencing in non-Hodgkin's lymphoma.

Authors : Heimann P, Dewispelaere L
Year : 2020
Journal : Curr Opin Oncol

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.

Authors : Kos Z, Roblin E, Kim RS, Michiels S, Gallas BD, Chen W, van de Vijver KK, Goel S, Adams S, Demaria S, Viale G, Nielsen TO, Badve SS, Symmans WF, Sotiriou C, Rimm DL, Hewitt S, Denkert C, Loibl S, Luen SJ, Bartlett JMS, Savas P, Pruneri G, Dillon DA, Cheang MCU, Tutt A, Hall JA, Kok M, Horlings HM, Madabhushi A, van der Laak J, Ciompi F, Lænkholm AV, Bellolio E, Gruosso T, Fox SB, Araya JC, Floris G, Hudecek J, Voorwerk L, Beck AH, Kerner J, Larsimont D, Declercq S, Van den Eynden G, Pusztai L, Ehinger A, Yang W, AbdulJabbar K, Yuan Y, Singh R, Hiley C, Bakir MA, Lazar AJ, Naber S, Wienert S, Castillo M, Curigliano G, Dieci MV, André F, Swanton C, Reis-Filho J, Sparano J, Balslev E, Chen IC, Stovgaard EIS, Pogue-Geile K, Blenman KRM, Penault-Llorca F, Schnitt S, Lakhani SR, Vincent-Salomon A, Rojo F, Braybrooke JP, Hanna MG, Soler-Monsó MT, Bethmann D, Castaneda CA, Willard-Gallo K, Sharma A, Lien HC, Fineberg S, Thagaard J, Comerma L, Gonzalez-Ericsson P, Brogi E, Loi S, Saltz J, Klaushen F, Cooper L, Amgad M, Moore DA, Salgado R
Year : 2020
Journal : NPJ Breast Cancer
Volume : 6
Pages : 17